Motif ID: NANOG{mouse}.p2

Z-value: 0.863


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_79419940.492.2e-01Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_56809594 1.079 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_-_123187842 0.851 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr1_-_28520379 0.694 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr12_-_123201319 0.652 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr11_-_72504643 0.582 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr10_+_129845806 0.577 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr22_+_45148437 0.573 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr6_-_2840683 0.513 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr8_+_28559010 0.486 EXTL3
exostoses (multiple)-like 3
chr6_+_90272036 0.454 NM_001242811
ANKRD6
ankyrin repeat domain 6
chrX_+_17653412 0.449 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr11_+_117947726 0.423 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr8_+_28559143 0.414 NM_001440
EXTL3
exostoses (multiple)-like 3
chr6_-_41130820 0.389 TREM2
triggering receptor expressed on myeloid cells 2
chr8_-_142264157 0.387 SLC45A4
solute carrier family 45, member 4
chr10_+_5566923 0.380 NM_005185
CALML3
calmodulin-like 3
chr11_+_117947785 0.362 TMPRSS4
transmembrane protease, serine 4
chr5_+_140220811 0.356 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr10_-_135090325 0.349 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr15_+_41136178 0.341 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr2_+_68961912 0.314 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr9_-_126030854 0.314 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr3_-_139258373 0.305 RBP1
retinol binding protein 1, cellular
chr12_+_105153258 0.304 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr9_-_126030792 0.303 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr16_+_3096681 0.298 NM_022468
MMP25
matrix metallopeptidase 25
chr8_-_91094924 0.283 NM_004929
CALB1
calbindin 1, 28kDa
chr11_-_51412447 0.282 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr12_-_58160823 0.279 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr17_-_7197866 0.278 NM_015982
YBX2
Y box binding protein 2
chr17_-_39274587 0.274 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr16_-_31147062 0.273 NM_002773
PRSS8
protease, serine, 8
chr17_-_7197896 0.273 YBX2
Y box binding protein 2
chr17_-_7197811 0.266 YBX2
Y box binding protein 2
chr11_+_6897855 0.264 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr15_+_44580935 0.261 CASC4
cancer susceptibility candidate 4
chr1_+_43735664 0.260 NM_144626
TMEM125
transmembrane protein 125
chr11_-_5462782 0.259 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr2_+_64681610 0.250 LGALSL
lectin, galactoside-binding-like
chr11_+_121461070 0.250 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_-_139258477 0.249 RBP1
retinol binding protein 1, cellular
chr19_-_54327428 0.247 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr3_+_31574119 0.247 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr12_-_85306579 0.239 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr7_+_144052432 0.229 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr7_-_143991255 0.221 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr19_+_50084586 0.220 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr3_-_151034514 0.218 NM_023915
GPR87
G protein-coupled receptor 87
chr15_+_90319588 0.209 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr11_+_34642587 0.208 NM_001206615
NM_012153
EHF

ets homologous factor

chr1_-_147245483 0.204 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr1_+_203097427 0.203 ADORA1
adenosine A1 receptor
chr6_-_20212628 0.201 NM_001080480
MBOAT1
membrane bound O-acyltransferase domain containing 1
chrX_+_138612894 0.194 NM_000133
F9
coagulation factor IX
chr19_-_38916801 0.190 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chrX_-_133792497 0.181 NM_021796
PLAC1
placenta-specific 1
chr14_+_21510384 0.180 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr14_+_76837689 0.176 NM_004452
ESRRB
estrogen-related receptor beta
chr3_+_31574431 0.175 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr20_+_44637539 0.169 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr3_-_57113292 0.166 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chrX_-_48828250 0.163 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr3_-_71803923 0.162 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr1_-_43424324 0.161 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr22_+_42095502 0.161 NM_152513
MEI1
meiosis inhibitor 1
chr6_+_160327972 0.159 NM_002377
MAS1
MAS1 oncogene
chr6_-_47009992 0.159 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr3_+_121774208 0.158 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr11_-_18270167 0.158 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr11_-_66488712 0.153 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chrX_-_80065182 0.151 NM_153252
BRWD3
bromodomain and WD repeat domain containing 3
chr14_-_94849552 0.151 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr8_+_95653399 0.150 ESRP1
epithelial splicing regulatory protein 1
chr11_+_12308446 0.147 NM_032867
MICALCL
MICAL C-terminal like
chr1_+_26856252 0.146 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_+_67344717 0.144 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr16_-_55989942 0.144 NM_001190158
CES5A
carboxylesterase 5A
chr6_-_43423785 0.143 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chrX_+_134124967 0.141 NM_001163438
CXorf69
chromosome X open reading frame 69
chr2_-_240322692 0.140 HDAC4
histone deacetylase 4
chr4_+_106816593 0.139 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr14_-_23285011 0.138 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_+_113875469 0.138 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr13_-_101327102 0.137 NM_001079669
NM_032813
TMTC4

transmembrane and tetratricopeptide repeat containing 4

chr10_-_69455926 0.136 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr4_-_82126200 0.134 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr8_+_31497267 0.133 NM_013962
NRG1
neuregulin 1
chr1_+_26856240 0.133 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_15848422 0.130 ADORA2B
adenosine A2b receptor
chr14_-_99737821 0.130 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr20_+_43343884 0.130 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr3_-_98241357 0.127 CLDND1
claudin domain containing 1
chr4_+_106816627 0.127 NPNT
nephronectin
chr19_+_2249112 0.126 NM_000479
AMH
anti-Mullerian hormone
chr1_+_156119734 0.125 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_+_73245192 0.125 NM_001305
CLDN4
claudin 4
chr14_-_91526912 0.124 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr11_-_5323174 0.122 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr6_+_106546736 0.121 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr1_+_26856259 0.121 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chrX_-_103174121 0.120 LOC100128594
uncharacterized LOC100128594
chr19_+_15197790 0.118 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chrX_+_48542193 0.117 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr12_-_123214882 0.116 NM_032554
HCAR1
hydroxycarboxylic acid receptor 1
chr20_+_43992087 0.116 SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr18_+_21452981 0.114 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr10_-_123357503 0.113 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr12_+_101188373 0.112 NM_178826
ANO4
anoctamin 4
chr5_+_139493689 0.111 NM_005859
PURA
purine-rich element binding protein A
chr3_+_42190736 0.110 TRAK1
trafficking protein, kinesin binding 1
chr20_-_21494663 0.109 NM_002509
NKX2-2
NK2 homeobox 2
chr22_-_39636906 0.109 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide
chr20_+_43991739 0.108 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr2_+_203499819 0.107 NM_173511
FAM117B
family with sequence similarity 117, member B
chr17_-_38073792 0.107 NM_018530
GSDMB
gasdermin B
chr1_+_220960038 0.106 NM_022746
MARC1
mitochondrial amidoxime reducing component 1
chr1_-_155959860 0.106 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_+_6887576 0.106 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr16_+_29674282 0.105 NM_001030288
SPN
sialophorin
chr10_+_123922940 0.105 TACC2
transforming, acidic coiled-coil containing protein 2
chr20_+_43344005 0.105 WISP2
WNT1 inducible signaling pathway protein 2
chr12_+_7942025 0.104 NANOG
Nanog homeobox
chr22_-_42084819 0.103 NM_001003796
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr2_-_133539627 0.103 NCKAP5
NCK-associated protein 5
chr17_+_7387688 0.102 NM_000937
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr4_+_123300120 0.101 NM_139243
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chr8_+_98881277 0.100 NM_002380
NM_030583
MATN2

matrilin 2

chr2_-_113594325 0.099 NM_000576
IL1B
interleukin 1, beta
chr10_-_131762374 0.098 EBF3
early B-cell factor 3
chr6_+_26087447 0.097 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr6_-_29343063 0.096 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr7_-_143956720 0.096 NM_001005328
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chr11_+_63871240 0.095 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr10_-_17171789 0.094 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr14_+_67999915 0.094 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chrX_-_120009778 0.094 NM_001145718
CT47B1
cancer/testis antigen family 47, member B1
chr16_+_56995761 0.093 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chrX_+_48916515 0.093 NM_001163322
NM_033626
NM_001163321
NM_001163323
CCDC120



coiled-coil domain containing 120



chr16_+_71560022 0.092 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr14_-_60632058 0.089 NM_016029
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr16_+_56817367 0.089 NM_001242796
NUP93
nucleoporin 93kDa
chr20_+_56285213 0.088


chr12_+_47610244 0.088 FAM113B
family with sequence similarity 113, member B
chr6_-_32160289 0.087 GPSM3
G-protein signaling modulator 3
chr18_+_55816546 0.087 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr1_-_35450902 0.087 ZMYM6NB
ZMYM6 neighbor
chr10_+_1034334 0.087 NM_012341
GTPBP4
GTP binding protein 4
chr2_+_64751545 0.086 AFTPH
aftiphilin
chr17_-_61777467 0.086 LIMD2
LIM domain containing 2
chr15_+_73976689 0.085 CD276
CD276 molecule
chr11_+_33563772 0.085 NM_012194
C11orf41
chromosome 11 open reading frame 41
chrX_+_105412297 0.084 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr1_+_159409511 0.084 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr22_+_26565454 0.084 SEZ6L
seizure related 6 homolog (mouse)-like
chr15_+_74833517 0.084 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr14_-_92198383 0.084 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr10_-_116418056 0.083 NM_002313
ABLIM1
actin binding LIM protein 1
chr10_-_48390873 0.082 NM_002900
RBP3
retinol binding protein 3, interstitial
chr2_+_220325533 0.082 NM_001173476
SPEG
SPEG complex locus
chr19_+_45843997 0.081 NM_177417
KLC3
kinesin light chain 3
chr4_+_24797084 0.080 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr4_-_120549115 0.080 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr8_-_103424897 0.080 NM_015902
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr12_-_57410275 0.080 NM_001178054
NM_013251
TAC3

tachykinin 3

chr14_+_23842017 0.079 NM_172314
NM_022789
IL25

interleukin 25

chrX_+_54556726 0.078 GNL3L
guanine nucleotide binding protein-like 3 (nucleolar)-like
chr18_+_13218777 0.078 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr19_-_3500937 0.078 NM_001145165
DOHH
deoxyhypusine hydroxylase/monooxygenase
chr7_+_148892553 0.077 NM_003575
ZNF282
zinc finger protein 282
chr2_-_183902747 0.077 NCKAP1
NCK-associated protein 1
chr10_+_24755459 0.077 KIAA1217
KIAA1217
chrX_-_24665454 0.076 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr20_+_58508818 0.076 NM_001190826
C20orf177
chromosome 20 open reading frame 177
chr22_+_41487787 0.076 EP300
E1A binding protein p300
chr3_-_122512526 0.075 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr8_+_124780679 0.074 FAM91A1
family with sequence similarity 91, member A1
chr22_-_51021337 0.072 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
CHKB-CPT1B readthrough (non-protein coding)
chr19_+_3178735 0.072 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr20_+_43343523 0.071 WISP2
WNT1 inducible signaling pathway protein 2
chr8_+_99956630 0.071 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr20_-_56284945 0.071 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_-_139258531 0.070 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr17_+_1646290 0.069 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr7_+_150382783 0.069 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr10_+_123923104 0.069 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr2_-_142889269 0.069 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr8_+_124780742 0.068 NM_144963
FAM91A1
family with sequence similarity 91, member A1
chr12_-_51477138 0.068 CSRNP2
cysteine-serine-rich nuclear protein 2
chr14_-_94856926 0.067 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr14_+_29236882 0.066 FOXG1
forkhead box G1
chr4_-_103266286 0.066 NM_022154
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_+_45772629 0.066 NM_014726
TBKBP1
TBK1 binding protein 1
chr14_+_29236171 0.066 NM_005249
FOXG1
forkhead box G1
chr3_-_196756682 0.065 NM_033316
NM_005929
MFI2

antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

chr4_+_24797203 0.065 SOD3
superoxide dismutase 3, extracellular
chr11_-_10715160 0.064 MRVI1
murine retrovirus integration site 1 homolog
chr10_-_126107454 0.064 OAT
ornithine aminotransferase
chr1_+_171810611 0.064 NM_001136127
NM_015569
DNM3

dynamin 3

chr2_-_97405775 0.064 LMAN2L
lectin, mannose-binding 2-like
chr11_-_10715297 0.063 MRVI1
murine retrovirus integration site 1 homolog

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
26.02 2.41e-02 GO:0015183 L-aspartate transmembrane transporter activity